Aim To investigate the effects of rosuvastatin on cardiac expression of adiponectin and its receptors in high-fat-fed rats. Methods Male Wistar rats （n＝48） were randomly divided into three groups: control group （NC）, high fat fed group （HF）, high fat fed＋rosuvastatin group （HF＋RS）. After 20 weeks, serum concentrations of triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterin （LDLC）, high density lipoprotein cholesterol （HDLC） and blood glucose （BG） were tested by automatic biochemical analyzer, serum level of adiponectin was measured by ELISA, the expression of adiponectin and its receptors in the myocardium was determined by RT-qPCR and Western blot. Results Compared with NC group, HF group showed increased serum TG, TC, LDLC, BG and adiponectin （P＜0.01）, and decreased serum HDLC （P＜0.01）. Compared with HF group, HF＋RS group showed decreased serum TG, TC, LDLC and adiponectin （P＜0.05）, increased serum HDLC （P＜0.01）, and with no obvious difference in serum BG （P＞0.05）. Compared with NC group, myocardial adiponectin expression were higher （P＜0.01）, myocardial adiponectin receptors expression were lower （P＜0.05） in HF group. Compared with HF group, myocardial adiponectin expression were downregulated （P＜0.05）, myocardial adiponectin receptor 1 expression were upregulated in HF＋RS group （P＜0.05）, while there was no obvious difference in myocardial adiponectin receptor 2 expression between the two groups （P＞0.05）. Conclusions There were elevation of serum adiponectin level and myocardial adiponectin expression, and reduction of myocardial adiponectin receptors expression in the process of feeding rats with high fat food. Rosuvastatin treatment could partly reverse these effects.