Aim To observe the effect of apolipoprotein A Ⅰ （ApoA Ⅰ） on the expression of inflammatory cytokines and explore the role of tristetraprolin （TTP）-translational modification in the ApoA Ⅰ inhibition macrophage-derived foam cells expression of inflammatory cytokines. Methods THP-1 macrophage-derived foam cells were treated with ApoA Ⅰ and/or lipopolysaccharide（LPS）. Enzyme linked immunosorbent assay was used to determine levels of interleukin-1β （IL-1β） in cell lysates. Real-time polymerase chain reaction was used to determine mRNA and degradation rate of IL-1β. Western blot was used to determine protein levels of TTP and p-TTP. Results ApoA Ⅰ significantly inhibited the levels of LPS-induced macrophage-derived foam cells inflammatory cytokines, and influenced the expression of TTP and TTP dephosphorylation. Conclusion ApoA Ⅰ inhibiting the expression of inflammatory cytokines in macrophage-derived foam cells may be involved in the dephosphorylation of TTP, which can bind and target ARE-containing mRNA for rapid degradation.