Aim To evaluate the predictive value of epicardial fat tissue （EFT） on coronary heat disease （CHD）. Methods Overall, 333 cases who underwent coronary angiography were classified into CHD groups and non-CHD group. EFT was measured by echocardiography. The obtained data was compared by receiver operating characteristic（ROC） curve and multi-logistic regression. Results The EFT in CHD group was significantly higher than that in non-CHD group （6.4±0.8 mm vs 4.8±0.7 mm, P<0.01）. ROC curve analysis showed EFT could reliably discriminate CHD patients （AUC: 0.834, 95% CI: 0.775～0.894, P<0.01）. Multivariate regression analysis also showed EFT was independent predictor of CHD ［OR5.17 （95% CI: 3.10～8.63）, P<0.01］. Conclusion This study showed EFT was independent predictor of CHD.