Aim To observe the effect of Shenshao oral lotion to blood lipid，hemorrheology，and stent restenosis in patients after percutaneous coronary coronary intervention （PCI）. Methods 1 023 patients with coronary heart disease were recruited into our study. Patients were randomly divided into two groups: conventional therapy group and ShenShao oral lotion taking group. Results The level of LDLC in patients of Shenshao oral lotion group decreased lower than that in conventional group in the same period. The indices of blood rheology in patients of Shenshao oral lotion were decreased lower than that in conventional therapy group. The late stage inner loss of the ShenShao oral lotion group was less than the conventional medicine group （P<0.05）. Conclusion Shenshao oral lotion could effectively prevent restenosis after PCI.