Aim To investigate the correlation of lacunar infarction with leukoaraisis and intracranial and extracranial artery stenosis. Methods 200 patients who admitted in the Department of Neurology，Beijing Military General Hospital from January 2012 to October 2012 were divided into lacunar infarction with leukoaraiosis group （n100） and lacunar infarction with non-Leukoaraiosis group （n100） according to their cerebral MRI findings, all of them were examined by head/neck CTA/MRA and it was determined whether leukoaraiosis is associated with intracranial or extracranial artery stenosis in patients with leukoaraiosis. Results The incidence rate of extracranial or intracranial artery stenosis in lacunar infarction with leukoaraiosis group was higher than lacunar infarction with non-leukoaraiosis. Severity of leukoaraiosis in patients with lacunar infarction was associated with extracranial or intracranial artery stenosis. Multiple regression showed age, history of hypertension, and artery plaques/stenosis were the strongest determinants of the leukoaraiosis severity. Conclusion The leukoaraiosis is associated with intracranial and extracranial artery stenosis in patients with lacunar infarction.