Diabetes mellitus is a risk equivalent of coronary heart disease and the pathogenesis of diabetic coronary atherosclerosis （As） is complicated,long-term hyperglycemia is recognized as the primary culprit for it can damage the endothelial cells persistently through interfering the intracellular signaling pathway and metabolism. Researches show that the increase of chronic inflammation and excessive oxidative stress is the most important pathophysiologic mechanisms for As and the common pathway of pathogenesis under the circumstance of hyperglycemia. In recent years,the study found that the hemoglobin scavenger receptor （CD163） has an obvious anti-inflammatory and anti-lipid peroxidation capacity and may play an important role in the prevention of diabetic coronary As.