Angiotensin converting enzyme (ACE) gene encodes an enzyme involved in catalyzing the conversion of angiotensin Ⅰ(AngⅠ) into a physiologically active peptide angiotensin Ⅱ(AngⅡ).AngⅡ is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance, at the same time ACE can function in the kallikrein-kinin system through inactivation of bradykinin to cause vasoconstriction, vascular permeability decrease and vascular response to stimulus enhancement.Recent studies have shown that the ACE gene polymorphism is closely related to cerebrovascular disease.This article will review some recent literatures on ACE gene polymorphism and its relevance to the cerebrovascular disease.