Endothelial microparticles (EMP) are small vesicles released from endothelial cells during their activation or apoptosis, a variety of disease states have elevated EMP content.In the pathogenesis of cardiovascular disease, EMP can initiates coagulation, participate in the inflammatory reaction, cause endothelial dysfunction, these all make great contribution to the pathogensis of cardiovascular disease.Improved knowledge of EMP composition and their biological effects will probably open new therapeutic approaches in the treatment of cardiovascular disease.