AimTo investigate the relationship between haemoglobin A1c (HbA1c) and arterial compliance in healthy individuals.Methods1175 healthy individuals were enrolled in a cross sectional study in coastal areas of Fujian Province.Brachial-ankle pulse wave velocity (BaPWV) and HbA1c were measured.Results(1) The BaPWV levels were significantly and positively correlated with HbA1c (r=0.147, P<0.05); (2) HbA1c levels were classified into quartile groups, and the BaPWV differences among the four groups were statistically significant (P<0.001); following the increase of HbA1c, pulse wave velocity increased, and the percentage of abnormal BaPWV increased gradually; The mean HbA1c of abnormal BaPWV group was higher (P<0.05); (3) BaPWV was independently associated with age, sysolic blood pressure, diastolic blood pressure, HbA1c, and uric acid by stepwise Logistic regression analysis (P<0.05), where HbA1c odds ratio was the biggest (OR=2692, P<0.05);ConclusionBaPWV was independently associated with HbA1c, suggesting that high blood glucose levels of the prediabetes were involved in the arterial wall of early functional or structural damage.