AimTo investigate the effect of atorvastatin and tinidazole control animation atherosclerosis and the elimination of periodontitis levels of tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) on the basis of animal models of atherosclerotic arteries with merged periodontitis.MethodsA total of 48 male New Zealand white rabbits with atherosclerosis and chronic periodontitis were randomly divided into 4 groups (n＝12): the control group, the atorvastatin group, the tinidazole group, the atorvastatin＋tinidazole group.Every group accepted the corresponding treatment.All the animals were sacrificed until 20 weeks, and the blood vessels were taken for quantitative determination by using quantitative polymerase chain reaction (PCR) technique.ResultsThe standard curve parameters of tumor necrosis factor, interleukin-1, interleukin-6 and β -actin standard Ct values of their corresponding serial dilutions of the standard concentration showed a good linear relationship (R2＞0.990) by melting the song in three kinds of inflammatory factors.The atorvastatin＋tinidazole group, the lowest detection rate was far lower than in control group (P<0.05), while the detection rate of the atorvastatin group and the tinidazole group (P<0.05) in the atorvastatin＋tinidazole group and control group.ConclusionAtorvastatin＋tinidazole can reduce the level of TNF, IL-1 and IL-6 in the rab-