AimTo investigate the role of endothelial damage related to septic myocardial injury.Methods 30 SpragueDawley rats were divided into 3 groups: shamoperation group, sepsis group and ulinastatin group.Plasma von Willebrand factor (vWF) and thrombomodulin (TM) levels were detected with ELISA, plasma creatine kinase (CK) and creatine kinase isoenzyme (CKMB) levels with reflotron plus clinical chemistry analyser, left ventricular pressure (LVP), the maximum and minimum rates of LVP change (＋dp/dtmax and －dp/dtmax) by cardiac catheterization and brain natriuretic peptide (BNP) levels by Western blot.ResultsPlasma CK, CKMB and cardiac BNP levels were elevated, LVP, ＋dp/dtmax and －dp/dtmax decreased as vWF and TM levels increased in sepsis group compared with those in shamoperation group.However, reduced myocardial injury and improved cardiac function were observed in ulinastatin group.ConclusionEndothelial damage in coronary probably contributes to sepsis induced myocardial injury.