AimTo discuss the correlation between leptin receptor (LEPR) gene polymorphism and patients of the Han nationality who suffer from hypertension and obesity in Yunnan region.MethodsSelect 283 hospitalized patients of the Han nationality who suffer from hypertension and obesity in yunnan region as hypertension group and select 153 healthy persons of the Han nationality as normal control group at the same time.According to body mass index (BMI) ≥28 kg/m², the hypertension group is divided into a group of 162 patients suffering from hypertension and obesity and a group of 121 patients suffering from hypertension but without obesity.Use polymerase even response-restriction fragment length polymorphism (PCR - RELP) method for determining Gln223Arg and Lys109Arg LEPR gene polymorphism, ELISA determination leptin levels in blood.Carotid intima-media thickness（CIMT） were measured by ultrasonography in all subjects.ResultsThe data of genotype frequency of Gln223Arg variant in leptin receptor gene between the case group and the control group had a significant difference (p<0.01).The data of genotype frequency of Lys109Arg variant in leptin receptor gene between the case group and the control group had no significant difference.Gln223Arg alleles LEPR gene frequency of A showed significant difference between the patients of hypertension with obesity and the patients of hypertension without obesity（p<0.01）.And patients of hypertension with obesity group has a higher CIMT（p<0.05）.LEPR gene Lys109Arg frequency showed no significant difference between the patients of hypertension with obesity and the patients of hypertension without obesity（p=0.226）.ConclusionLEPR gene polymorphism Gln223Arg was possibly associated with hypertension complicated with obesity in Han population in Yunnan area.And A allele is the risk factor to atherosclerosis in the patients of hypertension with obesity group.