Paraoxonase-3 (PON3) is a member of the paraoxonase (PON) family.In addition to PON3, it also includes PON1 and PON2.They share a large number of structural homology, and all the three proteins prevent oxidative stress and fight inflammation.They therefore seem central to a wide variety of human illnesses, including atherosclerosis, obesity, diabetes, inflammation bowel disorders and mental disorders.In vitro studies, the antioxidant capacity of PON3 is even stronger than PON1, so PON3 may also have the potential to become the treatment factors of certain diseases.The purpose of this review is to conclude some of the latest findings on PON3 in recent years, so as to provide new ideas for further research of the PON family.