AimTo investigate the association between circulating endothelial progenitor cells(EPC) and coronary heart disease(CHD) using a Meta analysis.MethodsMajor online database including Wanfang, CNKI, VIP, and PubMed were searched to collect case-control studies on the association between EPC and CHD published in China.The results were analyzed using RevMan 6.0 software.Funnel plot was made to confirm publication bias.Results Totally 14 studies containing 890 subjects were enrolled.The number of EPC colony forming units was counted under phase contrast microscope.Meta analysis showed that the number of EPC was significantly higher in patients with stable CHD than in control group (SMD=－2.81,95%CI (－4.03,－1.59), p<0.01).When the EPC specific surface mark were assessed by fluorescence activated cell sorter analysis, the result was similar(SMD=－1.85,95%CI(－2.95,－0.76), p<0.01).But the number of EPC was lower in patients with acute myocardial infarction than in control group.ConclusionsHigh EPC level is closely related with CHD.