AimThe study was designed to investigate the association between plasma concentrations of the soluble interleukin-1 receptor family member ST2 (sST2) and the degree of coronary artery stenosis in patients with acute myocardical infarction (AMI).MethodsPlasma soluble ST2 levels were measured via enzyme-linked immunosorbent assay (ELISA) in 44 AMI patients within 12 hours of the onset.The levels of coronary stenosis were assessed by Gensini scores and numbers of diseased vessels were counted.The association between plasma soluble ST2 level and coronary artery stenosis degree was analysed by SPSS software.ResultsIn AMI patients, the plasma sST2 was increased significantly in high Gensini scores subgroup (p<0.001) and a positive relation was found between sST2 levels and Gensini scores (r＝0.772, p<0.001).The plasma sST2 level was also significantly higher in patients with multivessels compared with single vessel (p<0.01).ConclusionThe levels of plasma soluble ST2 was positively correlated with severity of coronary stenosis and may predict the degrees of coronary stenosis in AMI patients.