AimTo investigate the effect of resveratrol on alcohol-induced myocardial fibrosis and the underlying molecular mechanism.MethodsMale Sprague-Dawley rats were divided into three groups: control group, alcohol group, and alcohol plus resveratrol group, 10 rats in each group.After the intervention for six months, the myocardial fibrosis was evaluated by Masson staining, the fibronectin expression in myocardium was evaluated by immunofluorescence, the expressions of matrix metalloproteinase (MMP)-2 and MMP-9 were determined by Western blot.ResultsAlcohol intake for six months caused a significant myocardial fibrosis and an obvious decrease in fibronectin.Oral administration with resveratrol partially reversed alcohol-induced myocardial fibrosis and fibronectin loss.Alcohol intake significantly increased the expressions of MMP-2 and MMP-9.Treatment with resveratrol remarkably attenuated alcohol-induced upregulations of MMP-2 and MMP-9.ConclusionResveratrol inhibits MMP-2 and MMP-9 and consequently prevents alcoholic myocardial fibrosis.