CD4⁺ and CD8⁺ T lymphocytes is significant during the development of atherosclerosis,and in recent years a growing number of studies have shown that the CD4⁺ and CD8⁺ T lymphocytes are involved in the immune and inflammatory responses of atherosclerosis which receives the attention of scholars home and abroad,and also becomes the challenge in the field of cardiovascular disease and immunology.In this paper,CD4⁺ and CD8⁺ T lymphocytes and atherosclerosis correlation research progress are reviewed.