Aim To study the association between von willebrand factor and brachial ankle pulse wave velocity in hypertensive patients.Methods 327 hypertensive patients who participated in the health examination in our hospital from May 2010 to August 2010 were recruited in our study.The von willebrand factor,brachial ankle pulse wave velocity and other biochemical indicator were collected.Comparison of the level of von willebrand factor and brachial ankle pulse wave velocity was analyzed among patients with different blood pressure.And the correlation between von willebrand factor,brachial ankle pulse wave velocity and blood pressure were performed.Results 209 males and 118 females with mean age 50.8±9.9 year participated in our study.The levels of von willebrand factor in mild,moderate or severe patients were 132.5%,148.7% and 164.3% respectively,and the difference was significant.The levels of brachial ankle pulse wave velocity in mild,moderate or severe patients were 1617.4 cm/s,1810.9 cm/s and 1896.1 cm/s respectively,and the difference was also significantly.The results of correlation showed a moderate correlation between von willebrand factor,brachial ankle pulse wave velocity and blood pressure.Conclusion The levels of von willebrand factor and brachial ankle pulse wave velocity increased simultaneously in hypertensive patients,and might play as predict factors in development of cardiovascular disease.