Aim Researching the correlation of atherosclerosis related genes and hyperlipidemia,in order to find atherosclerosis early diagnosis target.Methods Middle-aged male crab-eating Macaque(Macaca fascicularis) were fed moderately atherogenic diet(0.22 mg cholesterol/kcal and 40% of calories as saturated fat) for 12 months.According to blood-lipid hyperlipidemia crab-eating Macaques(n=10) were selected,then the expression differences of 113 atherosclerosis related genes were analysed by real-time PCR.Results 66 genes were detected in peripheral blood leucocyte.There were 18 genes upregulation and 21 genes downregulation with elevated blood lipid(P<0.05),besides 27 irregular genes.Conclusions Above result narrowed the scope of genes selection for further research,through further research we may select atherosclerosis early diagnosis target.