AimTo observe the effect of fluvastatin on the expression of matrix metalloproteinase-1(MMP-1), tissue inhibitors of matrix metalloproteinase-1(TIMP-1), and intracellular adhesion molecule-1(ICAM-1) induced by visfatin in cultured human umbilical vein endothelial cells（HUVEC）, and to explore the effect and mechanism of anti-inflammatory of fluvastatin.MethodsHUVEC were cultured in vitro, the HUVEC were pretreated with fluvastatin at different concentrations (10-7 mol/L,10-6 mol/L,10-5 mol/L) for 20 minutes before incubated with the visfatin of 800 μg/L for 24 hours.The cellular total RNA were extracted by TRNzol reagent.The expression of MMP-1, TIMP-1 and ICAM-1 mRNA were detected by reverse transcription-polymerase chain reaction (RT-PCR).The results of gel electrophoresis were analyzed with a computer scanning system.ResultsDifferent concentrations of fluvastatin could inhibit the expression of MMP-1 mRNA and ICAM-1 mRNA induced by visfatin in a dose-dependent manner.Different concentrations of fluvastatin could up-regulate the expression of TIMP-1 mRNA induced by visfatin.ConclusionFluvastatin could inhibit inflammatory response in vascular endothelial cells induced by visfatin in a dose-dependent manner, which could protect endothelial cells against the functional disorder, and prevent the development of atherosclerosis.