Hydrogen Sulfide Inhibits ox-LDL Uptake in THP-1-Derived Macrophages
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    Abstract:

    AimTo investigate the effects of hydrogen sulfide(H2S) on ox-LDL uptake of THP-1-derived macrophages and its underlying mechanisms. Methods Fluorescence microscopy, RT-PCR and western blot were performed. ResultsIncubation of macrophages with DiI-ox-LDL led to ox-LDL uptake of macrophages.Sodium hydrosulfide(NaHS, an H2S donor) decreased ox-LDL uptake. While DL-propargylglgycine (PPG) exerted opposite effects.Furthermore, ox-LDL markedly induced CD36 mRNA and protein expression in macrophages, which was abolished by NaHS (50 to 100 μmol/L), but enhanced by PPG. Conclusions H2S inhibits ox-LDL uptake of THP-1-derived macrophages and down-regulates CD36 mRNA and protein expression.

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ZHAO Zhan-Zhi, JIANG Zhi-Shen, YI Guang-Hui, TAN Jian-Miao, DENG Hua-Fei,,SUO Rong. Hydrogen Sulfide Inhibits ox-LDL Uptake in THP-1-Derived Macrophages[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2011,19(2):85-88.

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  • Received:December 20,2010
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