Apolipoprotein mimetic peptides that mimic the function of apolipoprotein with or without bearing the sequence homology to apolipoprotein have become a hot topic of atherosclerosis therapy research.The importance of apolipoprotein mimetic peptides in atherosclerosis and related disease was established by testing in animal models,and its potential usefulness in humans has been confirmed in preliminary studies.In this article,the development of apolipoprotein mimetic peptides is reviewed.