Aim To investigate the association between plasma lysophosphatidic(LPA) and coronary stenosis with coronary heart disease(CHD) as well as the roles of LPA in inflammation and lipidperoxidation. Methods Eighty-five patients were diagnosed as CHD according to the results of coronary angiography and ACC/AHA diagnostic criteria.The patients were divided into 3 groups: acute myocardial infarction(AMI) group(n=31),unstable angina(UA) group(n=30),stable angina(SA) group(n=24).Another 20 patients with normal coronary artery served as control.All patients underwent coronary angiography and the results were further evaluated by Jenkins score.The levels of plasma LPA and serum high sensitivity C-reactive protein(hs-CRP) and low density lipoprotein cholesterol(LDLC) were measured. Results The levels of LPA in AMI,UA and SA(4.85±0.36 μmol/L,3.67±0.84 μmol/L and 3.11±0.76 μmol/L) were significantly higher than that in the control group(2.15±0.57 μmol/L),the levels of LPA in AMI group were significantly higher than that in UA and SA,the levels of LPA in UA were significantly higher than that in the SA group(P><0.01).The levels of plasma LPA were positively correlated with Jenkins score(r=0.901,P><0.01),hs-CRP(r=0.755,P><0.01) and LDLC(r=0.549,P><0.01). Conclusion The levels of plasma LPA increased significantly in CHD patients and was positively related with coronary stenosis and serum hs-CRP and LDLC.