Growth differentiation factor-15 (GDF-15) which belongs to the GDF family is a member of TGF-β super family.The previous researches indicated that GDF-15 increased its expression in the condition of rheumatoid arthritis, inflammation, tumor, anemia and so on.During recent years, it was found that increased level of GDF-15 was associated with heart failure (HF), acute coronary syndrome (ACS), idiopathic pulmonary arterial hypertension (IPAH) and other cardiovascular diseases.GDF-15 which provides independent prognostic information in HF and other cardiovascular diseases might be a new promising biomarker.