Aim To explore the value of tissue doppler imaging in the evaluation of ventricular function in patients with end-stage renal disease. Methods 31 patients with end-stage renal disease of the normal eject factionand 31 healthy subjects were selected for routine 2D and tissue doppler imaging.Left ventricular eject faction,interventricular septum thickness,left ventricular posterior wall thickness,left ventricular internal dimensions and left ventricular internal dimensions were measured.Conventional left and right ventricular diastolic function parameters were acquired by pulsed doppler.Including to the mitral and tricuspid flow velocity,the ratio of the mitral and tricuspid early diastolic velocity and late diastolic velocity were calculated.The mitral and tricuspid annular early and late diastolic velocities were determined by tissue doppler imaging in apical views(4-and 2-chamber),and the ratio of the mitral and tricuspid early diastolic velocity and the mitral and tricuspid annular early diastolic velocities,and the ratio of the mitral and tricuspid annular early diastolic velocities and late diastolic velocities were calculated.Then function parameters of the end-stage renal disease group were compared with healthy group,and the corrections between the parameters were analyzed. Results The end-stage renal disease patients had lower ratio of the mitral and tricuspid early diastolic velocity and late diastolic velocity,the mean mitrial and tricuspid systolic velocities,the mean mitral and tricuspid annular early and late diastolic velocities,the mean ratio of the mitral and tricuspid annular early diastolic velocities and late diastolic velocities were significantly reduced,while the ratio of the mitral and tricuspid early diastolic velocity and the mitral and tricuspid annular early diastolic velocities was significantly increased. Conclusion Patients with end-stage renal disease had left and right ventriculars diastolic dysfunction,and so were systolic function.Systolic was impaired in patients with end-stage renal disease with normal ejection fraction.