CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice

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CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice
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                        Willeke de Haan1,Jitske de Vries-van der Weij2,4,Caroline C. van der Hoogt1,José W.A. van der Hoorn3,4,Johannes A. Romijn1,J. Wouter Jukema3,Louis M. Havekes1,3,4,Hans M.G. Princen4,Patrick C.N. Rensen1Willeke de Haan1,Jitske de Vries-van der Weij2,4,Caroline C. van der Hoogt1,José W.A. van der Hoorn3,4,Johannes A. Romijn1,J. Wouter Jukema3,Louis M. Havekes1,3,4,Hans M.G. Princen4,Patrick C.N. Rensen1
Departments of 1.General Internal Medicine,Endocrinology,and Metabolic Diseases,2.Human Genetics,and 3.Cardiology,Leiden University Medical Center,Leiden,The Netherlands; 4.TNO-Biosciences,Gaubius Laboratory,Leiden,The Netherlands.
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Background Cardiovascular disease (CVD) is mainly caused by atherosclerosis,for which dyslipidemia (i.e. high (V)LDL-cholesterol (C),high triglycerides and low HDLC is a major risk factor. To reduce the risk to develop CVD,patients with dyslipidemia are usually treated with lipid-lowering drugs including statins and fibrates.

Key words:Cholesteryl Ester Transfer Protein; Dyslipielemia; APOE*3-Leiden; High Density Lipoprotein Cholesterol; Very Low Density Lipoprotein

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Willeke de Haan, Jitske de Vries-van der Weij, Caroline C. van der Hoogt, José W. A. van der Hoorn, Johannes A. Romijn, J. Wouter Jukema, Louis M. Havekes, Hans M. G. Princen, Patrick C. N. Rensen. CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2009,17(7):574-575.

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