Aim To evaluate left cardiac function and morphology in patients with ventricular septal defect (VSD) after transcatheter closure by echocardiography.Methods In 60 patients with transcatheter closure of VSD by Amplatzer occluder,echocardiography examinations were performed to calculate left ventricular end-diastolic diameter (LVEDD),left ventricular end-dlastolic volume(LVEDV) left ventricular end-systolic volume(LVESV),left atrium endsystolic diameter(LAESD),left ventricular ejection fraction(LVEF),systolic movement velocities(S'),early diastolic movement velocities(E') and late diastolic movement velocities(L') 1 day before,3 days,3 months and 6 months after the closure respectively.Results LVEDD,LVEDV,LVESV,LAESD,LVEF,S',E' and L' of 3 and 6 months after transcatheter closure were lower than those of 1 day before transcatheter closure and 3 days after transcatheter closure(P<0.05 or 0.01).There were no difference between 3 days after transcatheter closure and 1 day before transcatheter closure (P>0.05).Conclusion Transcatheter closure of VSD can improve left cardiac function and geometric morphology, at the same time it can eliminate the abnormal shunt.