Aim To investigate the prognostic value of cardio-ankle vascular index(CAVI) in the occurrence of coronary heart disease(CHD).Methods 497 patients treated with coronary angiography were studied.All patients underwent cardio-ankle vascular index(CAVI) and serum factors evaluation in addition to history collection.The severity of coronary artery stenosis was evaluated by the number of diseased arteries and Gensini score.The risk factors of coronary heart disease and CAVI were compared between each group.The predicting role of these variables,especially CAVI,to the occurrence of CHD was analysed with Logistic regression.Results There were significant differences in sex composition,age,hypertension,diabetics,hyperlipidemia and cigarette smoking between the CHD group and the non-CHD group(P<0.05).The CAVI were significantly higher in patients with coronary artery disease than in the normal subjects(P<0.05).There was a positive linear trend between CAVI and Gensini's score(r=0.763,P<0.01). Multiple logistic analysis indicated that age,hypertension,diabetics,hyperlipidemia,cigarette smoking and CAVI were significantly correlated to the occurence of CHD(P<0.05).Conclusion Just like age,hypertension,diabetics,hyperlipidemia and cigarette smoking,CAVI were also independent risk factors of CHD.CAVI was an unattached predictor of the severity of coronary artery stenosis.