Aim To observe the clinical efficiency and safety of ozagrel sodium(OS) combined with Xueshuantong (XST) in treatment of patients with acute cerebral infraction(ACI).Methods 127 patients with acute cerebral infraction were randomly divided into control group,treatment group and combined-treatment group.The control group was given vinpocetine sodium chloride injection(VSCI).The treatment group was given OS.The combined-treatment group was given OS and XST(once a day for 14 days).All the patients were observed for the clinical efficiency and safety. Results Neurological function was significantly improved in the combined-treatment group as compared with the treated group and the control group after 7 days or 14 days of therapy(P<0.05).The total effective rate in combinedtreatment group was obviously higher than those in the treatment group and the control group(81.4%,54.7%and 52.4%,respectively P<0.05).No statistically significant difference was observed in the treatment group and the control group(P>0.05).No significant difference was observed in adverse effect in the three groups.Conclusion Ozagrel sodium combined with Xueshuantong in the treatment of patients with acute cerebral infraction is an effective and safe method.