Aim To explore the changes and related factors of pulse wave velocity(PWV)in hypertensive patients with obesity. Methods 300 hypertensive subjects in each group with or without obesity were enrolled.Brachial-ankle PWV(baPWV) in each patient were measured by using VP-1000 measurement system,and their blood glucose,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol, uric acid and waist circumference were determined.With BaPWV as the dependent variable and age,systolic blood pressure,diastolic blood pressure,pulse pressure,body mass index,waist circumference,blood glucose,triglycerides,total cholesterol,high density lipoprotein,creatinine,uric acid as independent variables,the multivariate analysis was made. Results BaPWV was significantly higher in hypertensive with obesity group(1635±239 cm/s)than those in simple hypertensive group(1583±288 cm/s;P<0.05). BaPWV was positively related to systolic blood pressure and pulse pressure(P<0.05),but not related to diastolic blood pressure(P>0.05).Multiple stepwise regression analysis showed that age,systolic blood pressure and waist circumference were closely related to baPWV as an arterial stiffness maker in the 600 hypertensive patients. Conclusions BaPWV has significant difference between hypertension complicated by obesity and simple hypertension.Age,systolic blood pressure and waist circumference are closely related to baPWV.