Aim To study the relationship between serum uric acid level and metabolic syndrome (MS) and its cardiovascular complication. Methods A total of 1000 subject with metabolic syndrome were enrolled in the study. MS was defined using NCEP-ATPⅢ criteria. The relationship between MS and its carvdiovascular complication and hyperuricemia were studied. Results The prevalence of hyperuricimia with MS was 53%. Uric acid level was the most significantly associated with blood pressure, triglycerides, waist circumference. Hyperuricemia was more common in men than in women, and was older than nohyperunicemia. Serum uric acid level was significantly associated with cardiovascular complication of MS. Conclusions The hyperuricermia was significantly associated with MS and its cardiovascular complication. The hyperuricermia may be an important part of MS and an important risk factor of cardiovascular diseases.