Aim To study the influence of immunological function on serum lipid level in patients with systemic lupus erythematosis (SLE). Methods Taking anticardiolipin antibody (ACL) and T-lymphocyte subsets counts as the starting points, the association between the immunological function and the serum lipid level including high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) and triglyceride (TG) levels were observed in 149 SLE inpatients. Results HDLC was significantly and negatively related to ACL (r=-0.448,P=0.005), while LDLC was positively related to C4 (r=0.427,P=0.007). Conclusion The aberrant humoral immunological functions in SLE patients may influence their serum lipid level.