Aim To study the levels of interleukin-17 (IL-17) and C-reactive protein (CRP) in plasma of aging coronary heart disease patients with depression. Methods The concentrations of IL-17 and CRP in plasma were examined by using enzym-linked immunosorbent assay in 68 aging coronary heart disease patients which were divided into two groups: depression group (n=38) and un-depression group (n=30). Results Concentrations of IL-17 and CRP were significantly higher in aging depression patients with coronary heart disease than those of the control group (341.72±134.28 ng/L vs 214.33±82.51 ng/L and 4.93±2.15 μg/L vs 1.93±1.25 μg/L, P<0.01). Levels of IL-17 and CRP in acute coronary syndrom were higher than that in stable angina patients (382.17±165.35 ng/L vs 305.47±119.75 ng/L and 5.96±2.31 μg/L vs 4.12±2.44 μg/L, P<0.01). Concentration of IL-17 in aging coronary heart disease patients with minor to moderate depression and major depression were significantly higher than those of non-depression patients (310.27±138.25 ng/L and 395.42±158.75 ng/L vs 214.33±82.51 ng/L, P<0.05), the concentrations of IL-17 major depression in aging coronary heart disease depression were higher than that of minor to moderate depression in aging patients with depression. The plasma levels of CRP in aging coronary heart disease patients with minor to moderate depression and major depression were increased as compared with the non-depression patients (4.35±2.01 ng/L and 5.84±1.87 ng/L vs 1.93±1.25 ng/L,P<0.05). The levels of major depression were increased as compared with minor to moderate depression patients. The levels of CRP were positively related with IL-17 in aging coronary heart disease patients with depression (r=0.802, P<0.05). The concentration of IL-17 and CRP were positively associated with the scores of depression (r=0.674, P<0.05; r=0.421,P<0.05). Conclusion Interleukin-17 and C-reactive protein play a role in the mechanism of aging coronary heart disease with depression.