Aim To analyse the cost and effect of nifedipine, captopril or combined treatment used as anti-essential hypertension therapy programs. Methods This study was a randomised single blind controlled clinical trial conducted in outpatient. The trial randomised 330 patients with mild to moderate hypertension aged 18～70 years were divided into three treatment groups: captopril (50 mg daily) group, nifedipine (40 mg daily) group, and captopril+nifedipine group for a mean follow up of 8 week. Results The effects of captopril group and nifedipine group after 8 week administration had similar result. But there was significant difference in blood pressure between captopril+nifedipine group and captopril or nifedipine group. Conclusion Nifedipine combined with captopril lowers blood pressure sufficiently to achieve therapeutic goal in most patients with hypertension.