Aim To evaluate the effect and diagnosis value on oxidized low density lipoprotein (ox-LDL) in the developing process of acute cerebral ischemia. Methods Eighty acute cerebral ischemia patients were chosen during June to August, 2007. These patients were divided two groups: the acute cerebral infarction (ACI) group and transient ischemic attack (TIA) group, based on the functional MR examination. The serum ox-LDL antibody was tested by enzyme-linked immunosorbent assay (ELISA) method, the main serum biochemistry indexes were detected to all patients and statistics analysis was performed. Results The patients in ACI group had a 38.07±32.14 ku/L ox-LDL antibody level and in TIA group had a 25.18±9.17 ku/L ox-LDL antibody level. A significant difference as compared with the patients in the twe group (P<0.05). The other biochemics index had no dependability in the two groups. Conclusions The patients with The ox-LDL antibody level is distinct in different type of cerebral ischemia patients and a higher level may give a danger signal with acute cerebra infarction.