Aim To evaluate the morphology of in-stent restenosis after different kinds of stents. Methods 846 lesions of patients who performed intracoronary interventional therapy and had angiographic follow-up in our cath lab were included in this study.Restenosis types of different drug eluting stents(DES) were analysed too. Results The focal proximal edge restenosis was 5.69% and 33.67% in bare mental stent(BMS) and DES respectively(P=0.000);Whereas the diffuse lesion in stent was 29.27% and 9.18%(P=0.000);Proliferative restenosis was 20.33% and 6.12%(P=0.003);The rate of total occlusion restenosis was 9.76% and 10.20%(P=0.912),while in DES the occlusion formed at proximal segment,and in BMS it formed in stent;Focal proximal edge restenois lesion was 47.06% and 25.00% in sirolimus eluting stent and taxol eluting stent(P=0.037);The diffuse in stent restenosis was 1.96% and 16.67%(P=0.018). Conclusion DES changed the morphology of in-stent restenosis,from diffuse restenosis to focal restenosis;Total occlusion restenosis rate in two different stents were same,but occlusion formed at proximal segment more commonly in DES while at in-stent in BMS;The diffuse restenosis lesion were common in taxus stent than that in other DES.