Aim To study the association between pulse pressure index(PPI) and serum insulin-like growth factor-1(IGF-1) in aged cases with essential hypertension(EH). Methods To detect serum IGF-1,and to calculate pulse pressure index in 132 aged cases in physical examination.Two groups were divided into EH group (99cases) and control group(33 cases).The EH group were divided into two sub-groups according to the PPI: normal PPI sub-group(PPI≤0.5) and high PPI subgroup(PPI>0.5).The difference of the IGF-1 and other data between two groups was compared.The relativity between PPI and other data in two groups was calculated with Pearson linear correlation analysis and multiple linear regression analysis. Results There were no obvious difference of the levels of IGF1 between two groups and between two sub-groups(P>0.05).Pearson linear correlation analysis showed that there was no correlation between PPI and IGF-1 in EH group.Multiple linear regression analysis showed that age was the independent influence factor of PPI(P=0.006)in EH group.In control group,Pearson linear correlation analysis showed that there was negative correlation between PPI and IGF-1(r=-0.736,P=0.000) and multiple linear regression analysis showed that IGF-1 was the independent influence factor of PPI(P=0.003). Conclusions In aged EH patients,there was no correlation between PPI and serum IGF-1.In healthy old people,there was negative correlation between PPI and serum IGF-1.