Aim To explore and establish a new pig model of acute myocardial infarction. Methods Self-made copper-stents were implanted in left anterior descending coronary arteries of 16 pigs.Troponin I,echocardiography,coronary angiography,electrocardiogram and pathologic evaluation were performed to confirm AMI at one week after procedure. Results The model of myocardial infarction was successfully established in 14 of the 16 pigs and the success rate was 87.5%(14/16).One pig had sudden death at 8 hours and another died during anaesthesia at one week after procedure. Conclusion The method of establishing the pig model of myocardial infarction by implanting copper-stent in coronary artery is simple,convenient,safe and has a relatively high success rate and low mortality.