Effect of Interferon-γ on the CXC Ligand 16 Expression and the Lipid Accumulation in the Rat Aortic Smooth Muscle Cells
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    Abstract:

    Aim To investigate whether CXC ligand 16(CXCL16) expressions were controlled by interferon-gamma(IFN-γ) secreted by the activated T cells and the effect on lipid accumulation in the rat aortic smooth muscle cells(SMC). Methods The cells were grown to confluence and then incubated with different concentration of IFN-γ.The CXCL16 expression was identified by reverse transcription polymerase chain reaction(RT-PCR);The effect of IFN-γ on oxidized low density lipoprotein(ox-LDL) uptake was identified by high performance liquid chromatography(HPLC) analysis. Results The CXCL16 mRNA expression was significantly increased after IFN-γ treatment;The rat aortic SMC lipid accumulation after IFN-γ treatment was increased in treated cells compared with untreated cells. Conclusion The T cell cytokine IFN-γ induces CXCL16 mRNA expression in rat aortic SMC and then leads to lipid accumulation in rat aortic SMC.

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YANG Ting, and QUAN Zhi-Hua. Effect of Interferon-γ on the CXC Ligand 16 Expression and the Lipid Accumulation in the Rat Aortic Smooth Muscle Cells[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2008,16(3):185-188.

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History
  • Received:October 24,2007
  • Revised:February 25,2008
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