Aim To evaluate the therapeutic effect of sodium ozagrel on treatment of transient ischemic attack(TIA).Methods 70 cases of TIA patients were allocated randomly into treatment group and treated control group(35 cases in every group).The treatment group was given 80 mg of sodium ozagrel intravenously twice a day and Ligustrazine 80 mg intravenously once a day,the treated control group was given 80 mg Ligustrazine once a day,both groups were given 5 000 u low molecular weigh heparin subcutaneously twice a day and 100 mg asprin once a day.Carotid internal-media thickness(IMT) and arterial plaque of all patients and normal controls were measured by carotid ultrasonography.The platelet aggregation rate and fibrinogen level were observed in both treatment groups before and after 14 d treatment.The cerebralvascular events were observed in 30 d.Results The difference of fibrinogen level and platelet aggregation rate in the treatment group was significant compared with the treated control group(P<0.05).The difference of IMT and percentage of carotid arterial plaque in the 70 cases of TIA was significant compared with the normal controls(P<0.01).Compared with the treated control group,the cerebralvascular events in the treatment group decreased(P<0.01).Conclusion Sodium ozagrel is effective and safe in treatment of TIA and progress the prognosis.