Aim Aim To evaluate the short-term efficacy of percuteoust transluminal septal myocardial ablation(PTSMA) on hyoertrophic obstructive cardiomyopathy(HOCM). Methods 29 patients with HOCM were selected underwent PTSMA by Sigwart method.The change of left ventricular outflow-tract gradient(LVOTG) and ECG were monitored before and after septal branche occluded by 99% alcohol.The thickness of septal myocardium and width of left ventricular end-diastolic diameter(LVEDD) were also measured before and 30 days after PTSMA.Results LVOTG was dereased by 36.0±9.3 mmHg after ablation respectively(p< 0.05).The thickness of septal myocardium reduced by 3.2±0.3 mm,30 days after ablation(p<0.05).Nonsustained ventricular tachycardia,bradycardias,bundle branch block and completely atrial-ventricular block were not observed in 30 days.The average usage of alcohol was 2.97 mL.Conclusion PTSMA can significantly reduce LVOTG and has a satisfactory short-term efficacy in the treatment of HOCM.