Aim To study the biocompatibility of Dacron vascular prosthesis surface in rabbit model coated with 2-methacryloyloxyethyl phosphorylcholine(MPC) by ozonization.Methods Dacron vascular prosthesis was exposed to ozone and then followed by grafted polymerization with MPC.Pruned the vascular prothesis coated with MPC and patched the abdomenal aorta of twelve rabbits(treated group) controlled with uncoated grafts.The patency rate of abdomenal aorta,level of anastomotic stenosis,volume of blood flow of vascular prosthesis and the BrdU labeling index were observed.Results After patched the abdomenal aorta of rabbits using different Dacron vascular prosthesis,there was no significant difference in the patency rate between the two groups.Level of stenosis in anastomotic area was less in treated group than control group.The BrdU labeling index in neointimal tissue and smooth muscle around stoma was significantly less(p< 0.05) in the treated group than in the control group.Conclusions These data demonstrated that Dacron vascular prosthesis coated with MPC significantly reduces anastomotic intima and smooth muscle hyperplasia,reduces level of anastomotic stenosis and increase volume of blood flow of vascular prosthesis.