Aim To discover the level and the relationship of the homocysteic acid(HCY),blood fat,fasting blood glucose(FBG)and glycosylated hemoglobin(HbAlc)in the type Ⅱ diabetes with eyeground vascular sclerosis.Methods The HCY,blood fat,FBG and HbAlc were detected in the 37 type Ⅱ diabetes with eyeground vascular sclerosis,compared with those of 45 healthy cases.Results The HCY,triglyeride(TG),total cholesterol,apolipoprotein A,FBG and HbAlc were more higher than those of healthy person(p<0.05 or 0.01).Conclusion The levels of the HCY,TG,FBG,HbAlc in the type Ⅱ diabetes with eyeground vascular sclerosis related to degree of eyeground vascular desease.