Effects of Stromal Cell-Derived Factor-1α on Proliferation and Migration of Rat Bone Marrow Derived Endothelial Progenitor Cells
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    Abstract:

    Aim To study whether stromal cell-derived factor-1α (SDF-1α) have effects on endothelial progenitor cells (EPC) and its preliminary mechanism. Methods Bone marrow derived EPC were aquried by Micropore-method and characterized by immunofluorescence staining. The abilities of migration were detected by the methods of transwell migration after EPC treated with different concentrations of SDF-1α. Results SDF-1α promoted EPC biologic activity of migration in a concentration-dependent manner (P<0.05 or P<0.01). Conclusion SDF-1α can improve migration of EPC.

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TONG Zhong-Yi, WANG Zuo, JIANG Zhi-Sheng, SONG Yan-Ming, ZHOU Xiao-Feng,,TIAN Yong-Feng. Effects of Stromal Cell-Derived Factor-1α on Proliferation and Migration of Rat Bone Marrow Derived Endothelial Progenitor Cells[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2007,15(7):491-493.

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History
  • Received:June 04,2007
  • Revised:June 25,2007
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