Aim To study whether stromal cell-derived factor-1α (SDF-1α) have effects on endothelial progenitor cells (EPC) and its preliminary mechanism. Methods Bone marrow derived EPC were aquried by Micropore-method and characterized by immunofluorescence staining. The abilities of migration were detected by the methods of transwell migration after EPC treated with different concentrations of SDF-1α. Results SDF-1α promoted EPC biologic activity of migration in a concentration-dependent manner (P<0.05 or P<0.01). Conclusion SDF-1α can improve migration of EPC.