Aim To investigate the effects of atorvastatin treat on secretion of prostaglandin I₂(PGI₂)and monocyte chemoattractant protein-1(MCP-1)in cultured rat artery endothelail cells(RACE).Methods RACE were cultured within basal medium.When cells grew to the stage of confluence,50 mmol/L homocysteine(HCY)and variant concentration of atorvastatin(5,15,30 and 50 mmol/L)were added,for another 8 hours.PGI₂ and MCP-1 were examined in nutrient solution.Results RAEC were injured severely by HCY.Within atorvastatin medium,PGI₂ increased and MCP-1 decreased.This effect was dose-depenedent.Conclusion Atorvastatin reduce MCP-1 and increase PGI₂ secretion in damaged RAEC.