Aim To evaluate the clinic significance of antibodies to oxidized low density lipoprotein(ox-LDL) in the patients of coronary artery disease(CHD). Method The target population was divided into four groups by his clinic syndrome: stable angina pectoris(SAP);unstable angina pectoris(UAP);acute myocardium infarction(AMI);normal control group(CON).Antibodies to ox-LDL in serum of the patients was measured by enzyme linked immunosorbent assay(ELISA).The stenosis degree of coronary artery was quantitative assayed by Gemini marker. Results The titre of antibodies to ox-LDL in the patients of CHD was obviously higher,especially in the ACS,than that in CON.The titre increased in hysteretic mode,which was highest 7～10 days after hospitalization and was most obviously different between groups.There was no statistical dependence between the titer of antibodies and the stenosis degree of coronary artery. Conclusions There is a positive correlation between the titer of antibodies to ox-LDL and the clinical manifestation of CHD,which reveals that autoimmunity may play an important role in the origin,progress of atherosclerosis(As).And the titer of antibodies to ox-LDL is hoped to be an important marker to evaluate the risk of As.