Aim To study the changes of secretory type Ⅱphospholipase A2(sPLA2) in coronary heart disease(CHD) and the relationship with high sensitive Creactive protein(hs-CRP). Methods According to clinical syndrome and angiography,110 patients were enrolled as acute coronary syndrome(ACS) group,63 patients as stable coronary heart(SCHD) disease(SCHD) group and 89 non-CHD patients as control group.Serum levels of sPLA2 was measured by enzyme linked immunosorbent assay(ELISA) in all subjects and the relationship with hs-CRP was studied. Results Compared with control group,the level of serum sPLA2 was higher in CHD group(55.18±11.75 ku/L vs 68.15±16.70 ku/L,p<0.01),which was also higher in ACS group than that in SCHD group(71.32±18.07 ku/L vs 62.63±11.92 ku/L,p<0.01).The level of serum sPLA2 was positively correlated with hs-CRP. Conclusion The increasing level of serum sPLA2 is correlated with CHD and the stability of coronary plaque.sPLA2 may be one of the important inflammation indicators in patients with coronary artery disease.