Effect of Xuezhikang on Matrix Metalloproteinase-2,9 in Acute Coronary Syndromes Patients
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    Abstract:

    Aim To investigate the effect of Xuezhikang on matrix metalloproteinase-2,9(MMP-2,9)in acute coronary syndromes(ACS) patients. Methods Xuezhikang were administered in thirty ACS patients.MMP-2,9 and pro MMP-2,9 were evaluated before administration,after 7 days and 30 days by SDS-PAGE enzymograph.The normal control group included twenty-five volunteers. Results Serum MMP-2 and pro MMP-2 elevated significantly in ACS group compared with control group(p<0.01).No differences in MMP-2,9 and pro MMP-2,9 existed before administration and after 7 days in patients with ACS.Serum MMP-2 after 30 days in ACS patients elevated significantly than that before administration(p<0.05). Conclusions Serum MMP-2 and pro MMP-2 elevated significantly in ACS patients and Xuezhikang could decrease the levels of serum MMP-2 and pro MMP-2.

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ZHANG Jing~,XING Yue~,XU Xiao-Fei~,and MENG Xiao-Ping~. Effect of Xuezhikang on Matrix Metalloproteinase-2,9 in Acute Coronary Syndromes Patients[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2006,14(7):623-624.

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History
  • Received:September 26,2005
  • Revised:July 15,2006
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