The Effect of Azithromycin on Inflammation Reaction in Atherosclerosis Rabbits
Author:
  • Article
  • | |
  • Metrics
  • | |
  • Related [20]
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Aim To investigate the relationship between atherosclerosis(As) and inflammation and the effect of azithrumycin on As rabbits. Methods 45 rabbits were divided into control group,high lipid group and azitheromycin group.The latter 2 groups were made as modle by high lipid feeding [cholesterol 1.5 g/(kg·d)] and vascular intimal injury.Azithromycin group were given azithromycin 30 mg/(kg·d) 3 days 4weeks.High sensitivity C-reactive protein(hs-CRP),Chlamydia pneumoniae immunoglobulin G(CPIgG) were detected at 0,4th,8th,and 12th week.The damaged segments of abdominal artery were harvested for morphometry and reverse transcription polymerase chain reaction evaluated the mRNA expression of vascular cell adhesion molecule-1(VCAM-1). Results High-lipid As rabbit had higher level of hs-CRP(212.8±5.3 g/L),CPIgG(2.03±0.08 g/L) and mRNA expression of VCAM-1(1.102±0.108) than azithromycin group(hs-CRP: 123.9±2.1 g/L,CPIgG: 1.40±0.09 g/L,VCAM-1 mRNA: 0.978±0.135).Azithromycin could reduce the levels of these inflammation indexes. Conclusion As had relationship with inflammation,azithromycin could inhibit inflammation and inhibit As.

    Reference
    Cited by
Get Citation

ZHANG Zi-Xin, ZHAO Wei-Hua, SONG Li-Xin, and ZENG Ding-Yin. The Effect of Azithromycin on Inflammation Reaction in Atherosclerosis Rabbits[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2006,14(7):601-603.

Copy
Related Videos

Share
Article Metrics
  • Abstract:1190
  • PDF: 1006
  • HTML: 0
  • Cited by: 0
History
  • Received:November 22,2005
  • Revised:June 27,2006
Article QR Code